Alprazolam triazolobenzophenone

Alprazolam prodrug

Alprazolam triazolobenzophenone is a chemical compound that is a prodrug for the benzodiazepine derivative alprazolam. At neutral pH it readily cyclizes to alprazolam, while in acidic conditions alprazolam undergoes a ring-opening reaction back to the ketone. A series of related acyl derivatives was researched in the 1980s as injectable water-soluble prodrugs of alprazolam, but were never developed for medical use. Subsequently, this compound has been detected as a designer drug, first being identified from a seizure in Spain in March 2014.

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