Bursa of Fabricius

Specialized organ in birds

In birds, the bursa of Fabricius is the site of hematopoiesis. It is a specialized organ that, as first demonstrated by Bruce Glick and later by Max Dale Cooper and Robert Good, is necessary for B cell development in birds. Mammals generally do not have an equivalent organ; the bone marrow is often the site of both hematopoiesis and B cell development. The bursa is present in the cloaca of birds and is named after Hieronymus Fabricius, who described it in 1621.

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