Citrate synthase

Enzyme found in humans

Citrate synthase is an enzyme that exists in nearly all living cells. It functions as a pace-making enzyme in the first step of the citric acid cycle. Citrate synthase is located within eukaryotic cells in the mitochondrial matrix, but is encoded by nuclear DNA rather than mitochondrial. It is synthesized using cytoplasmic ribosomes, then transported into the mitochondrial matrix.

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