Keywords

#complement-dependent_cytotoxicity

Complement-dependent cytotoxicity

Complement-dependent cytotoxicity (CDC) is an effector function of IgG and IgM antibodies. When they are bound to surface antigen on target cell, the classical complement pathway is triggered by bonding protein C1q to these antibodies, resulting in formation of a membrane attack complex (MAC) and target cell lysis.

Sun 28th

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Complement-dependent cytotoxicity Antibody-dependent cellular cytotoxicity Cytotoxicity Passive antibody therapy Cancer immunotherapy Panel-reactive antibody Monoclonal antibody Rituximab CD20 Donor-specific antibody
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