Diglyceride acyltransferase

Class of enzymes

Diglyceride acyltransferase, DGAT, catalyzes the formation of triglycerides (triacylglycerols) from diacylglycerol and acyl-CoA. The reaction catalyzed by DGAT is considered the terminal and only committed step in the acyl-CoA-dependent triglyceride synthesis, universally important in animal, plants, and microorganisms. The conversion is essential for intestinal absorption and adipose tissue formation in mammalian. DGAT1 are homologous to other membrane-bound O-acyltransferases, but not all other DGATs.

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