Left-right asymmetry

Early process which breaks bilateral symmetry during embryonic development

In developmental biology, left-right asymmetry is the process in early embryonic development that breaks the normal symmetry in the bilateral embryo. In vertebrates, left-right asymmetry is established early in development at a structure called the left-right organizer and leads to activation of different signalling pathways on the left and right of the embryo. This in turn causes several organs in adults to develop LR asymmetry, such as the tilt of the heart, the different number of lung lobes on each side of the body, and the position of the stomach and spleen on the right side of the body. If this process does not occur correctly in humans it can result in heterotaxy or situs inversus.

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