List of phenyltropanes

Phenyltropanes (PTs) are a family of chemical compounds originally derived from structural modification of cocaine. The main feature differentiating phenyltropanes from cocaine is that they lack the ester functionality at the 3-position terminating in the benzene; and thusly the phenyl is attached direct to the tropane skeleton with no further spacer that the cocaine benzoyloxy provided. The original purpose of which was to extirpate the cardiotoxicity inherent in the local anesthetic "numbing" capability of cocaine while retaining stimulant function. These compounds present many different avenues of research into therapeutic applications, particularly in addiction treatment. Uses vary depending on their construction and structure-activity relationship ranging from the treating of cocaine dependency to understanding the dopamine reward system in the human brain to treating Alzheimer's and Parkinson's diseases. Certain phenyltropanes can even be used as a smoking cessation aid. Many of the compounds were first elucidated in published material by the Research Triangle Institute and are thus named with "RTI" serial-numbers Similarly, a number of others are named for Sterling-Winthrop pharmaceuticals and Wake Forest University. The following includes many of the phenyltropane class of drugs that have been made and studied.

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