Lomentospora prolificans

Species of fungus

Lomentospora prolificans is an emerging opportunistic fungal pathogen that causes a wide variety of infections in immunologically normal and immunosuppressed people and animals. It is resistant to most antifungal drugs and infections are often fatal. Drugs targeting the Class II dihydroorotate dehydrogenase (DHODH) proteins of L. prolificans, Scedosporium, Aspergillus and other deadly moulds are the basis for at least one new therapy, Olorofim, which is currently in phase 2b clinical trials and has received breakthrough status by FDA. For information on all DHODH proteins, please see Dihydroorotate dehydrogenase.

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