Lugaro cell

Lugaro cells are primary sensory interneurons of the cerebellum, that have an inhibitory function. They are fusiform, having a spindle shape that tapers at each end. They were first described by Ernesto Lugaro in the early 20th century. Lugaro cells are found just beneath the layer of Purkinje cells between the molecular layer and the granular layer. They have thick principal dendrites coming from opposite poles of their bodies. These dendrites are very long and travel along the boundary between the Purkinje layer and the granular layer. They seem to contact from 5 to 15 Purkinje cells in a horizontal direction. They can also sense stimuli close to the Purkinje cells and their dendrites form a large receptive area that monitors the environment near to the Purkinje cells. Whilst their dendrites make contact with the Purkinje cells they also receive inputs from branches of the Purkinje axons by which they seem to have a sampling and integration role.

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