Missouri Route 115

State highway in eastern Missouri

Route 115 is a highway in the St. Louis, Missouri area. Its western terminus is at exit 237 of Interstate 70 (I-70) in Berkeley near Lambert-St. Louis International Airport. Route 115's eastern terminus is also at I-70, at exit 248A, in St. Louis, near the McKinley Bridge. The road is locally known as Natural Bridge Road, Natural Bridge Avenue, and Salisbury Street. It is one of two Missouri Highways that has an odd-numbered designation, yet runs in an east–west direction.

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