Moist desquamation

Moist shedding of the skin following radiation exposure

Moist desquamation is a description of the clinical pattern seen as a consequence of radiation exposure where the skin thins and then begins to weep because of loss of integrity of the epithelial barrier and decreased oncotic pressure. Moist desquamation is a rare complication for most forms of radiology, however it is far more common in fluoroscopy where threshold doses lie between 10-15 Gy and increasingly common above 15 Gy. It has been noted that fractionation of fluoroscopic procedures significantly reduces the likelihood of moist desquamation occurring. In animal studies done on pig skin, moist desquamation was found to occur with a 50% of the time after a single dose of 28 Gy, however a 2×18 Gy fractionation scheme was needed to produce the same 50% occurrence.

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