Keywords

#paroxysmal_cold_hemoglobinuria

Paroxysmal cold hemoglobinuria

Medical condition

Paroxysmal cold hemoglobinuria (PCH) or Donath–Landsteiner hemolytic anemia (DLHA) is an autoimmune hemolytic anemia featured by complement-mediated intravascular hemolysis after cold exposure. It can present as an acute non-recurrent postinfectious event in children, or chronic relapsing episodes in adults with hematological malignancies or tertiary syphilis. Described by Julius Donath (1870–1950) and Karl Landsteiner (1868–1943) in 1904, PCH is one of the first clinical entities recognized as an autoimmune disorder.

Thu 18th

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Paroxysmal cold hemoglobinuria Paroxysmal hemoglobinuria Paroxysmal nocturnal hemoglobinuria Cold sensitive antibodies Cold agglutinin disease Cold autoimmune hemolytic anemia Autoimmune hemolytic anemia Hematologic disease Warm antibody autoimmune hemolytic anemia List of hematologic conditions
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