Polar overdominance

Polar overdominance is a unique form of inheritance originally described in livestock, with relevant examples in humans and mice being discovered shortly after. The term polar is used to describe this type of overdominance because the phenotype of the heterozygote is more prevalent than the other genotypes. This polarity is shown as differential phenotype is only present in one of the heterozygote configurations when the recessive allele is inherited in a parent of origin type fashion. Polar overdominance differs from regular overdominance where both heterozygote genotypes display a phenotype that has increased fitness regardless of the parent of origin. Studying this type of inheritance could have practical applications in preventative medicine for humans as well as a variety of other agricultural applications.

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