Polygalacturonase inhibitor

Part of enzyme inhibition

Polygalacturonase inhibitor proteins (PGIPs), also known as polygalacturonase-inhibiting proteins, are plant proteins capable of inhibiting the action of polygalacturonase (PG) enzymes produced by bacterial and fungal pathogens. PGs can be produced by pathogens to degrade the polygalacturonan component of plant cell walls. PGIPs are leucine-rich repeat glycoproteins of approximately 360 amino acids in length, and PGIPs may reduce the activity of PGs by one or two orders of magnitude. Both competitive and non-competitive inhibition has been observed for various PGIPs. However, no inhibition of endogenous plant PGs that participate in fruit ripening by PGIPs have been reported.

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