Shunting inhibition

Shunting inhibition, also known as divisive inhibition, is a form of postsynaptic potential inhibition that can be represented mathematically as reducing the excitatory potential by division, rather than linear subtraction. The term "shunting" is used because of the synaptic conductance short-circuit currents that are generated at adjacent excitatory synapses. If a shunting inhibitory synapse is activated, the input resistance is reduced locally. The amplitude of subsequent excitatory postsynaptic potential (EPSP) is reduced by this, in accordance with Ohm's Law. This simple scenario arises if the inhibitory synaptic reversal potential is identical to or even more negative than the resting potential.

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